Zarzio 48 Mu/0.5 Ml

4 min read Jun 26, 2024
Zarzio 48 Mu/0.5 Ml

Zarzio 48 MU/0.5 mL: An Overview

What is Zarzio?

Zarzio is a medication used to treat various bone marrow disorders, including chronic neutropenia, aplastic anemia, and cancer. It is a type of recombinant human granulocyte-colony stimulating factor (G-CSF) that helps to stimulate the production of white blood cells in the body.

Zarzio 48 MU/0.5 mL: Indications

Zarzio 48 MU/0.5 mL is specifically indicated for the following conditions:

Chronic Neutropenia

  • Congenital neutropenia
  • Idiopathic neutropenia
  • Cyclic neutropenia

Aplastic Anemia

  • Acquired aplastic anemia
  • Fanconi anemia


  • Chemotherapy-induced neutropenia
  • Radiation-induced neutropenia

How Does Zarzio Work?

Zarzio works by stimulating the production of granulocytes, a type of white blood cell that helps fight infection. It does this by binding to specific receptors on the surface of bone marrow cells, triggering a response that leads to the production and release of granulocytes into the bloodstream.

Administration and Dosage

Zarzio 48 MU/0.5 mL is administered via subcutaneous injection, usually once daily. The dosage and duration of treatment may vary depending on the specific condition being treated and the patient's response to therapy.

Side Effects

Common side effects of Zarzio include:

  • Bone pain
  • Muscle pain
  • Fatigue
  • Headache
  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain

Less common but more serious side effects may include:

  • Allergic reactions
  • Anaphylaxis
  • Capillary leak syndrome
  • Sickle cell crisis
  • Leukocytosis


Zarzio is contraindicated in patients with:

  • Allergy to filgrastim or any other component of the medication
  • Sickle cell disease
  • Severe congenital neutropenia (Kostmann's syndrome)

Pregnancy and Breastfeeding

Zarzio is classified as category C during pregnancy, meaning it should only be used if the potential benefits outweigh the potential risks. It is not known whether Zarzio is excreted in human milk, and therefore, caution should be exercised when administering the medication to nursing mothers.

Storage and Handling

Zarzio 48 MU/0.5 mL should be stored in the refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). It should not be frozen or shaken. The medication should be administered within the expiration date indicated on the packaging.


Zarzio 48 MU/0.5 mL is a valuable medication for the treatment of various bone marrow disorders. While it can cause side effects, its benefits often outweigh the risks, especially for patients with severe neutropenia. However, it should only be used under the guidance of a healthcare professional and with careful monitoring of the patient's response to therapy.

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